Sophie Peskett's goal meant that the Eagles were trailing at half-time, but second-half strikes from Weerden and Abbie Larkin helped Palace earn all three points at the JobServe Community Stadium.
Weerden gave her thoughts at full-time on a dramatic 90 minutes in Colchester: "First of all, I'm out of breath. I'm dead. I think that sums up the game. It was a hard game.
"The first half we weren't good enough. We were chaotic, we were not clean with our passes, the duels. But I think in the second half we turned it around and I think we had some good attacks.
"We were more clean with the ball, we created more chances. Like our Manager said, you create your own luck and I think today we really did that."
